Invitrogen™ ABHD4 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA575867

Catalog No. PIPA575867

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

The α/β hydrolase superfamily is comprised of diverse members that are involved in important biochemical processes and related to various diseases. They have unrelated sequences, various substrates, and different kinds of catalytic activities, yet they share the same canonical α/β hydrolase fold, which consists of an eight-stranded parallel α/β structure. They are also characterized by a catalytic triad composed of a histidine, an acid and a nucleophile. Members of this superfamily are often drug targets for treating diseases, such as diabetes, Alzheimer's disease, obesity and blood clotting disorders. ABHD1 plays a role in metabolizing smoking xenobiotics. ABHD2 participates in the development of atherosclerosis. ABHD4 is involved in an alternative synthesis pathway of NAE. ABHD4 is a lysophospholipase selective for N-acyl phosphatidylethanolamine (NAPE) which participates in the biosynthesis of N-acyl ethanolamines. Mutations in ABHD5 contribute to Chanarin-Dorfman syndrome. ABDH6 may play a role in nervous system metabolism and signaling. ABHD14A is possibly involved in granule neuron development.

Specifications

• Antigen: ABHD4
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ABHD4
• Gene Alias: (Lyso)-N-acylphosphatidylethanolamine lipase; (Lyso)-N-acylphosphatidylethanolamine lipase; protein ABHD4; 1110035H23Rik; Abh4; Abhd4; abhydrolase domain containing 4; abhydrolase domain containing 4, N-acyl phospholipase B; abhydrolase domain-containing protein 4; AI429574; Alpha/beta hydrolase domain-containing protein 4; alpha/beta-hydrolase 4; hypothetical protein LOC509896; lyso-N-acylphosphatidylethanolamine lipase; protein ABHD4
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 105501, 364380, 63874
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q8TB40, Q8VD66
• Gene Symbols: ABHD4
• Immunogen: Synthetic peptide corresponding to residues in Human ABHD4.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG