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Invitrogen™ ABRA1 Monoclonal Antibody (ABRA1-01)
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Catalog No. PIMA110045
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100 μg
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Catalog No. Quantity
PIMA110045 100 μg
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Catalog No. PIMA110045 Supplier Invitrogen™ Supplier No. MA110045
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Description

Mouse Monoclonal Antibody

This antibody recognizes human ABRA1 (Abraxas, CCDC98), an adaptor protein involved in DNA repair, which migrates as a 45 kDa band on PAAGE under reducing conditions.

CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ABRA1
Applications Flow Cytometry, Immunoprecipitation, Western Blot
Classification Monoclonal
Clone ABRA1-01
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 15mM sodium azide; pH 7.4
Gene Abraxas1
Gene Accession No. Q6UWZ7
Gene Alias 3830405G04Rik; 5630400M01Rik; ABRA1; abraxas protein; Abraxas1; AI506069; AL024423; AV118690; BRCA1-A complex subunit Abraxas; BRCA1-A complex subunit Abraxas 1; Ccdc98; coiled-coil domain containing 98; coiled-coil domain-containing protein 98; FAM175A; family with sequence similarity 175 member A; family with sequence similarity 175, member A; FLJ11520; FLJ12642; FLJ13614; Protein FAM175A; RGD1305287; UNQ496/PRO1013
Gene Symbols Abraxas1
Host Species Mouse
Immunogen Recombinant protein corresponding to amino acids 1-313 of ABRA1 with N-terminal His6 tag.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84142
Target Species Human
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG2a κ
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Safety and Handling

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