Invitrogen™ ABRA1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA558042

Catalog No. PIPA558042

Description

Immunogen sequence: CNYNHHLDVV DNLTLMVEHT DIPEASPAST PQIIKHKTLD LDDRWQFKRS RLLDTQDKRS KADTGSSNQD KASKMSSPET DEEIEKMKGF GEYSRSPT Highest antigen sequence identity to the following orthologs: Mouse - 51%, Rat - 50%.

CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist.

Specifications

• Antigen: ABRA1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Abraxas1
• Gene Alias: 3830405G04Rik; 5630400M01Rik; ABRA1; abraxas protein; Abraxas1; AI506069; AL024423; AV118690; BRCA1-A complex subunit Abraxas; BRCA1-A complex subunit Abraxas 1; Ccdc98; coiled-coil domain containing 98; coiled-coil domain-containing protein 98; FAM175A; family with sequence similarity 175 member A; family with sequence similarity 175, member A; FLJ11520; FLJ12642; FLJ13614; Protein FAM175A; RGD1305287; UNQ496/PRO1013
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 84142
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 0.05 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q6UWZ7
• Gene Symbols: Abraxas1
• Immunogen: Recombinant protein corresponding to Human ABRA1. Recombinant protein control fragment (Product #RP-102777).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov