Abraxas Polyclonal Antibody, Bethyl Laboratories

Catalog No.	Quantity
50-157-2434	10 μL
50-157-2433	100 μL

Catalog No. 50-157-2434 Supplier Bethyl Laboratories, Inc Supplier No. IHC00630T

Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Orangutan, Monkey, Crab-eating macaque and White-tufted-ear marmoset

CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist.

Specifications

• Antigen: Abraxas
• Applications: Immunohistochemistry
• Classification: Polyclonal
• Conjugate: Unconjugated
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene: ABRAXAS1
• Gene Accession No.: Q6UWZ7
• Gene Alias: UNQ496/PRO1013, ABRA1, CCDC98, FLJ11520, FLJ12642, FLJ13614, BRCA1-A complex subunit Abraxas, abraxas protein, coiled-coil domain containing 98, coiled-coil domain-containing protein 98
• Gene Symbols: ABRAXAS1
• Host Species: Rabbit
• Immunogen: Between 400 and 409
• Purification Method: Antigen affinity chromatography
• Quantity: 10 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 84142
• Target Species: Human
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG