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Tocris Bioscience™ ABT 737
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Catalog No. 683510
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68-351-0 10 mg
68-355-0 50 mg
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Catalog No. 68-351-0 Supplier Tocris Bioscience™ Supplier No. 6835/10
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Description

Bcl-2 family inhibitor; mimics BH3 and induces apoptosis in cancer cell lines

ABT 737 is a high affinity Bcl-2 family inhibitor (Ki ≤ 1nM for Bcl-XL, Bcl-2 and Bcl-w). BH3 mimetic; triggers Bax/Bak-mediated apoptosis. Exhibits cytotoxicity in lymphoma cell lines overexpressing bcl-2 (EC50 < 1 μM) and multiple myeloma cells (IC50 = 5-15 μM). Induces apoptosis in patient-derived CLL cells. Promotes regression of SCLC tumors in a mouse xenograft model. Synergizes with certain other anticancer agents.

Specifications

Quantity 10 mg
Molecular Formula C42H45ClN6O5S2
Formula Weight 813.43
Product Type Inhibitor
Purity 98%
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