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  5. Tocris Bioscience™ AC 1903

Tocris Bioscience™ AC 1903
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Catalog No. 676625
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25 mg
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67-662-5 25 mg
67-665 5 mg
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Catalog No. 67-662-5 Supplier Tocris Bioscience™ Supplier No. 6766/25
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Description

Selective TRPC5 blocker

AC 1903 is a selective TRPC5 blocker (IC50 = 13.6 μM). Also displays weak inhibition at TRPC4 (IC50 >100 μM) but not TRPC6. Exhibits no effect against a standard panel of profiling kinases. Blocks TRPC5 channel activity in glomeruli of proteinuric rats. Suppresses severe proteinuria and prevents podocyte loss in a transgenic rat model of focal segmental glomerulosclerosis (FSGS).

Specifications

Chemical Name or Material N-(2-Furanylmethyl)-1-(phenylmethyl)-1H-benzimidazol-2-amine
CAS 831234-13-0
Quantity 25 mg
Molecular Formula C19H17N3O
Formula Weight 303.36
Purity 98%
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