Tocris AC 5216
Selective TSPO ligand
Manufacturer: Tocris 5281/50
DescriptionLigand of translocator protein (TSPO, peripheral benzodiazepine receptor). Exhibits high affinity for TSPO in rat whole brain (Ki = 0.297nM), and high potency against human and rat glial TSPO (IC50 values are 2.73 and 3.04nM respectively). Displays no noticeable binding to a number of other receptors, transporters or ion channels. Also displays anxiolytic and antidepressant effects in rodent models, without inducing benzodiazepine-like adverse effects.
- Chemical Name: N-Ethyl-7,8-dihydro-7-methyl-8-oxo-2-phenyl-N-(phenylmethyl)-9H-purine-9-acetamide
- Formula: C23H23N5O2
- CAS Number: 226954-04-7
- Solubility: Soluble to 100mM in DMSO and to 10mM in ethanol with sonication
- Purity: >98
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