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Invitrogen™ ACAP2 Polyclonal Antibody
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Catalog No. PIPA518209
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100 μg
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Catalog No. Quantity
PIPA518209 100 μg
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Catalog No. PIPA518209 Supplier Invitrogen™ Supplier No. PA518209
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Description

Goat Polyclonal Antibody

This antibody is predicted to react with canine and porcine based on sequence homology. This antibody is tested in Peptide ELISA: antibody detection limit dilution 32,000.

ACAP2 is a transport carrier belonging to the Centaurin family with three ANK repeats, an Arf-GAP domain, a BAR domain, and a PH domain. ACAP2, a GTPase-activating protein (GAP) for ADP ribosylation factor 6 (ARF6) has robust constitutive ARF6 GAP activity, where the GAP activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and phosphatidic acid but has little activity toward ARF1 and is known to control the return of ARF to the inactive GDB-bound shots. ACAP2, along with ACAP1, is targeted by phosphatidyl inositol (3, 4, 3) triphosphate inhibiting the formation of PDGF-induced dorsal membrane ruffles in NIH3T3 fibroblasts when overexpressed. ACAP2 is phosphorylated upon DNA damage, probably by ATM or ATR. Expression is wide-spread with the highest level in lung.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ACAP2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.5% BSA and 0.02% sodium azide; pH 7.3
Gene ACAP2
Gene Accession No. Q15057, Q5FVC7, Q6ZQK5
Gene Alias 4832442G16; 9530039J15Rik; ACAP2; Arf GAP with coiled coil, ANK repeat and PH domains 2; arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2; ArfGAP with coiled-coil, ankyrin repeat and PH domains 2; centaurin beta2; centaurin, beta 2; centaurin-beta-2; Centb2; CNT-B2; KIAA0041; mKIAA0041
Gene Symbols ACAP2
Host Species Goat
Immunogen Synthetic peptide sequence (EKLNRFQQDSQKF) corresponding to the C-terminus amino acids of ACAP2 (aa 766-778).
Purification Method Antigen affinity chromatography, Ammonium sulfate precipitation
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 23527, 619382, 78618
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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WARNING: Cancer - www.P65Warnings.ca.gov
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