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ACD Monoclonal Antibody (OTI1C8), TrueMAB™, OriGene
SDP

Catalog No. 501674937
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30 μL
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Catalog No. Quantity
50-167-4937 100 μL
50-254-0454 30 μL
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Catalog No. 50-167-4937 Supplier OriGene Supplier No. TA504201
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Description

Mouse Monoclonal Antibody

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.

Specifications

Antigen ACD
Applications Immunocytochemistry, Immunofluorescence, Western Blot
Classification Monoclonal
Clone OTI1C8
Concentration 0.72 mg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
Gene ACD
Gene Accession No. Q96AP0
Gene Alias PIP1, PTOP, TINT1, TPP1
Gene Symbols ACD
Host Species Mouse
Immunogen Full length human recombit protein of human ACD produced in HEK293T cell.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 65057
Target Species Human
Content And Storage -20° C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG2b
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