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ACD Mouse anti-Human, Clone: OTI2B1, lyophilized, TrueMAB™
SDP

Mouse Monoclonal Antibody

Supplier:  OriGene CF504379

Encompass_Preferred

Catalog No. 50-166-2852


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Description

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.
Specifications

Specifications

ACD
Monoclonal
Unconjugated
ACD
PIP1, PTOP, TINT1, TPP1
Mouse
Affinity Chromatography
RUO
65057
-20° C, Avoid Freeze/Thaw Cycles
Lyophilized
Immunohistochemistry (Paraffin), Western Blot
OTI2B1
PBS with 8% trehalose and no preservative; pH 7.3
Q96AP0
ACD
Full length human recombit protein of human ACD produced in HEK293T cell.
100 μg
Primary
Human
Antibody
IgG1
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