ACD Mouse anti-Human, Clone: OTI2B1, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF504379

Catalog No. 50-166-2852

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.

Specifications

• Antigen: ACD
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: ACD
• Gene Alias: PIP1, PTOP, TINT1, TPP1
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 65057
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI2B1
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q96AP0
• Gene Symbols: ACD
• Immunogen: Full length human recombit protein of human ACD produced in HEK293T cell.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1