Invitrogen™ ACE Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA578711

Catalog No. PIPA578711

Description

Reconstitute with 0.2 mL of distilled water to yield a concentration of 500 μg/mL. Positive Control - WB: rat lung tissue, mouse lung tissue, human Raji whole cell. IHC: human lung cancer tissue, human thyroid cancer tissue, mouse lung tissue, rat lung tissue IHC-F: human placenta tissue, mouse lung tissue. ICC/IF: A431 cell.

This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Two most abundant alternatively spliced variants of this gene encode two isozymes-the somatic form and the testicular form that are equally active. Multiple additional alternatively spliced variants have been identified but their full length nature has not been determined.

Specifications

• Antigen: ACE
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Ace
• Gene Alias: ACE; ACE1; ACE-T; angiotensin 1 converting enzyme 1; angiotensin converting enzyme; angiotensin converting enzyme, somatic isoform; angiotensin I converting enzyme; angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; angiotensin I converting enzyme 1; angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript; angiotensin I-converting enzyme (Dipeptidyl carboxypeptidase 1); angiotensin-converting enzyme; Angiotensin-converting enzyme, soluble form; angiotensin-converting enzyme; LOW QUALITY PROTEIN: angiotensin-converting enzyme; angiotensin-converting enzyme-like; AW208573; carboxycathepsin; CD143; CD143 antigen; DCP; Dcp1; dipeptidyl carboxypeptidase 1; Dipeptidyl carboxypeptidase 1 (Angiotensin I-converting enzyme); dipeptidyl carboxypeptidase I; dipeptidyl peptidase; I79_009670; ICH; kininase II; LOC103158533; MGC26566; MVCD3; peptidase P; peptidyl dipeptidase i; StsRR92; testicular ECA
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11421, 1636, 24310
• Content And Storage: -20°C
• Form: Lyophilized

• Applications: Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 500 μg/mL
• Formulation: PBS with 5mg BSA and 0.05mg sodium azide
• Gene Accession No.: P09470, P12821, P47820
• Gene Symbols: Ace
• Immunogen: E.coli-derived human ACE recombinant protein (Position: K651-Y864).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov