ACE2 Mouse anti-Human, Clone: OTI4C5, lyophilized, TrueMAB™

Mouse Monoclonal Antibody

Supplier:  OriGene CF803844

Catalog No. 50-166-6696

Description

Reconstitute with PBS (pH 7.3) and recommend to perform another round of desalting process using Product No. 7KMWCO

Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.

Specifications

• Antigen: ACE2
• Classification: Monoclonal
• Conjugate: Unconjugated
• Gene: ACE2
• Gene Alias: ACEH
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 59272
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI4C5
• Formulation: PBS with 8% trehalose and no preservative; pH 7.3
• Gene Accession No.: Q9BYF1
• Gene Symbols: ACE2
• Immunogen: Human recombit protein fragment corresponding to amino acids 18-237 of human ACE2 produced in E.coli.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1