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Invitrogen™ ACE2 Polyclonal Antibody
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Catalog No. PIPA520040
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100 μg
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Catalog No. Quantity
PIPA520040 100 μg
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Catalog No. PIPA520040 Supplier Invitrogen™ Supplier No. PA520040
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Description

Rabbit Polyclonal Antibody

In Western blot applications, this antibody detects a band at ~90kDa. A suggested positive control is human kidney tissue lysate. PA5-20040 can be used with blocking peptide PEP-0159.

Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ACE2
Applications Immunohistochemistry (Paraffin), Immunohistochemistry (PFA fixed), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% sodium azide
Gene ACE2
Gene Accession No. Q5EGZ1, Q8R0I0, Q9BYF1
Gene Alias 2010305L05Rik; ACE 2; Ace2; ACEH; ACE-related carboxypeptidase; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; angiotensin-converting enzyme 2; Angiotensin-converting enzyme homolog; anigotensin I converting enzyme 2; anigotensin-converting enzyme-related carboxypeptidase; metalloprotease MPROT15; peptidyl-dipeptidase A; Processed angiotensin-converting enzyme 2; renal angiotensin-converting enzyme 2; UNQ868/PRO1885
Gene Symbols ACE2
Host Species Rabbit
Immunogen A synthetic peptide corresponding to amino acids near the C-terminus of human ACE2.
Purification Method Antigen affinity chromatography
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 302668, 59272, 70008
Target Species Human, Mouse, Rat
Content And Storage 4°C
Product Type Antibody
Form Liquid
Isotype IgG
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