ACE2 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-173-3264	Proteintech Group Inc 211151AP150UL	150 μL

Description

This antibody is specific to ACE2.

Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.

Specifications

• Antigen: ACE2
• Applications: Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse, Rat
• Gene Accession No.: Q5EGZ1, Q8R0I0, Q9BYF1
• Gene ID (Entrez): 302668, 59272, 70008
• Immunogen: ACE2 Fusion Protein Ag15455
• Primary or Secondary: Primary
• Content And Storage: -20°C
• Gene: ACE2

• Concentration: 0.43 mg/mL
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Alias: ACE related carboxypeptidase, ACE2, ACEH, Angiotensin converting enzyme 2, Metalloprotease MPROT15
• Gene Symbols: ACE2
• Isotype: IgG
• Purification Method: Antigen Affinity Chromatography
• Product Type: Antibody