Invitrogen™ ACER3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5101416

Catalog No. PIPA5101416

Description

Antibody detects endogenous levels of total PHCA.

ACER3 is a protein coding gene. Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma. Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function. By regulating the levels of proinflammatory ceramides in immune cells and tissues, may modulate the inflammatory response.

Specifications

• Antigen: ACER3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ACER3
• Gene Alias: 1110057L18Rik; 5430429L08Rik; Acer3; alkaline CDase 3; alkaline ceramidase 3; Alkaline dihydroceramidase SB89; alkaline phytoceramidase; AlkCDase 3; aPHC; AV015045; Phca; phytoceramidase, alkaline; RGD1561254
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 499210, 55331, 66190
• Content And Storage: -20°C
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q9D099, Q9NUN7
• Gene Symbols: ACER3
• Immunogen: A synthesized peptide derived from human ACER3(Accession Q9NUN7), corresponding to amino acid residues T177-G227.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov