Invitrogen™ ACER3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA549661

Catalog No. PA549661

Description

ACER3 Polyclonal Antibody for Western Blot, Flow

ACER3 is a protein coding gene. Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma. Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function. By regulating the levels of proinflammatory ceramides in immune cells and tissues, may modulate the inflammatory response.

Specifications

• Antigen: ACER3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ACER3
• Gene Alias: 1110057L18Rik; 5430429L08Rik; Acer3; alkaline CDase 3; alkaline ceramidase 3; Alkaline dihydroceramidase SB89; alkaline phytoceramidase; AlkCDase 3; aPHC; AV015045; Phca; phytoceramidase, alkaline; RGD1561254
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography, Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 55331, 66190
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Flow Cytometry, Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 0.09% sodium azide; pH 7.4
• Gene Accession No.: Q9D099, Q9NUN7
• Gene Symbols: ACER3
• Immunogen: KLH conjugated synthetic peptide between 224-250 amino acids from the C-terminal region of human ACER3.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG