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Invitrogen™ ACER3 Polyclonal Antibody
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Catalog No. PIPA584834
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100 μL
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PIPA584834 100 μL
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Catalog No. PIPA584834 Supplier Invitrogen™ Supplier No. PA584834
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: DREGYWGPTT STLDWCEENY SVTWYIAEFW NTVSNLIMII PPMFGAVQSV RDGLEKR Highest antigen sequence indentity to the following orthologs: Mouse - 82%, Rat - 82%.

ACER3 is a protein coding gene. Endoplasmic reticulum and Golgi ceramidase that catalyzes the hydrolysis of unsaturated long-chain C18:1-, C20:1- and C20:4-ceramides, dihydroceramides and phytoceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH. Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation. Controls the generation of sphingosine in erythrocytes, and thereby sphingosine-1-phosphate in plasma. Through the regulation of ceramides and sphingosine-1-phosphate homeostasis in the brain may play a role in neurons survival and function. By regulating the levels of proinflammatory ceramides in immune cells and tissues, may modulate the inflammatory response.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ACER3
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.05 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene ACER3
Gene Accession No. Q9NUN7
Gene Alias 1110057L18Rik; 5430429L08Rik; Acer3; alkaline CDase 3; alkaline ceramidase 3; Alkaline dihydroceramidase SB89; alkaline phytoceramidase; AlkCDase 3; aPHC; AV015045; Phca; phytoceramidase, alkaline; RGD1561254
Gene Symbols ACER3
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human ACER3. Recombinant protein control fragment (Product #RP-108561).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 55331
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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