Invitrogen™ H2A.ZK7ac Recombinant Rabbit Monoclonal Antibody (RM222)

Rabbit Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA524665

Catalog No. PIMA524665

Description

This antibody reacts to Histone H2A.Z acetylated at Lysine 7 (K7ac). No cross reactivity with non-modified Lysine 7 or other acetylated Lysines in histone H2A. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene encodes a member of the histone H2A family, and generates two transcripts through the use of the conserved stem-loop termination motif, and the polyA addition motif.

Specifications

• Antigen: H2A.ZK7ac
• Classification: Recombinant Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH 7.2-7.4
• Gene Accession No.: P0C0S5, Q71UI9
• Gene Symbols: H2AZ1, H2az2
• Immunogen: Acetyl-peptide corresponding to Acetyl-Histone H2A.Z (Lys7).
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

• Applications: ChIP Assay, ELISA, Western Blot, Luminex, Immunocytochemistry
• Clone: RM222
• Conjugate: Unconjugated
• Gene: H2AZ1
• Gene Alias: 11ac; Acetyl-Histone H2A.Z K7; Acetyl-Histone H2A.Z Lys7; H2A histone family member Z; H2A histone family, member Z; H2A.z; H2A.Z-1; H2A.ZK5; H2A.ZK5ac; H2A.ZLys7ac; H2A/z; H2AFZ; H2AFZac; H2AZ; H2AZ histone; H2AZK11ac; H2AZK7ac; H2AZLys7ac; histone H2A.Z
• Host Species: Rabbit
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 3015, 94239
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid