Invitrogen™ H2BK20ac Recombinant Rabbit Monoclonal Antibody (RM235)

Catalog No.	Quantity
PIMA524698	100 μg

Catalog No. PIMA524698 Supplier Invitrogen™ Supplier No. MA524698

Description

Rabbit Recombinant Monoclonal Antibody

This antibody reacts to Histone H2B acetylated at Lysine 20 (K20ac). No cross reactivity with non-modified Lysine 20 or other acetylated Lysines in histone H2B. Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The nucleosomes wrap further and compact DNA into chromotin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones play a central role in transciption regulation, DNA repair, DNA replication, and chromosomal stability. H2B has a broad antibacterial activity.

Specifications

• Antigen: H2BK20ac
• Applications: ChIP Assay, ELISA, Western Blot, Luminex, Immunocytochemistry
• Classification: Recombinant Monoclonal
• Clone: RM235
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH 7.2-7.4
• Gene: H2BC12
• Gene Accession No.: A0A2R8Y619, O60814, P06899, P0C1H6, P23527, P33778, P57053, P58876, P62807, Q16778, Q5QNW6, Q7Z2G1, Q8N257, Q93079, Q96A08, Q99877, Q99879, Q99880
• Gene Alias: 2610022J01Rik; Acetyl-Histone H2; Acetyl-Histone H2B K20; Acetyl-Histone H2B Lys20; AV127319; bA317E16.3; dJ160A22.3; dJ193B12.2; dJ221C16.3; dJ221C16.6; dJ221C16.8; dJ97D16.4; GL105; H2B; H2B 291A; H2B 291B; H2b 613; H2B GL105; H2B histone family member M; H2B histone family member W testis-specific; H2B histone family member W, testis specific; H2B histone family, member A; H2B histone family, member B; H2B histone family, member C; H2B histone family, member D; H2B histone family, member E; H2B histone family, member F; H2B histone family, member J; H2B histone family, member K; H2B histone family, member L; H2B histone family, member M; H2B histone family, member N; H2B histone family, member Q; H2B histone family, member R; H2B histone family, member S; H2B histone family, member T; H2B histone family, member U, (testis-specific); H2B histone family, member W, testis-specific; H2B K; H2B type 12; H2B.1; H2B.1A; H2B.1B; H2B.2; H2B/a; H2B/b; H2B/c; H2B/d; H2B/e; H2B/f; H2B/g; H2B/h; H2B/I; H2B/j; H2B/k; H2B/l; H2B/n; H2B/q; H2B/r; H2B/S; h2B-143; h2B-221; H2b-291b; H2b-613; H2Bb; H2BC10; H2BC4; H2BC6; H2BC7; H2BC8; H2b-f; H2BFA; H2BFAiii; H2BFB; H2BFC; H2BFD; H2BFE; H2BFF; H2BFG; H2BFH; H2BFJ; H2BFK; H2BFL; H2BFM; H2BFN; H2BFQ; H2BFR; H2bfs; H2BFT; H2BFU; H2BFWT; H2BGL105; H2BJ; H2b-j; H2BK; H2BK12ac; H2BK15ac; H2BK5ac; H2b-l; H2BLys20ac; H2b-n; H2BQ; H2BS14; H2BS14p; HIRA-interacting protein 1; HIRA-interacting protein 2; HIRIP1; HIRIP2; HIST1H2BA; HIST1H2BB; HIST1H2BC; HIST1H2BD; Hist1h2be; Hist1h2bf; HIST1H2BG; Hist1h2bh; HIST1H2BI; Hist1h2bj; Hist1h2bk; HIST1H2BL; Hist1h2bm; Hist1h2bn; HIST1H2BO; HIST1H3I; Hist2h2be; HIST2H2BF; Hist3h2bb; histone 1, H2ba; histone 1, H2bb; histone 1, H2bc; histone 1, H2bd; histone 1, H2bg; histone 1, H2bh; histone 1, H2bi; histone 1, H2bj; histone 1, H2bk; histone 1, H2bl; histone 1, H2bm; histone 1, H2bn; histone 1, H2bo; histone 2, H2be; Histone 2B; histone 3, H2bb; histone cluster 1, H2ba; histone cluster 1, H2bb; histone cluster 1, H2bc; histone cluster 1, H2bd; histone cluster 1, H2bg; histone cluster 1, H2bh; histone cluster 1, H2bi; histone cluster 1, H2bj; histone cluster 1, H2bk; histone cluster 1, H2bl; histone cluster 1, H2bm; histone cluster 1, H2bn; histone cluster 1, H2bo; histone cluster 2, H2be; histone cluster 2, H2bf; histone cluster 3, H2bb; histone family member; histone H2B; histone H2B type 1-A; Histone H2B type 1-B; histone H2B type 1-C/E/F/G/I; Histone H2B type 1-C/E/G; histone H2B type 1-D; Histone H2B type 1-F/J/L; histone H2B type 1-H; Histone H2B type 1-J; histone H2B type 1-K; Histone H2B type 1-L; histone H2B type 1-M; Histone H2B type 1-N; histone H2B type 1-O; Histone H2B type 2-E; histone H2B type 2-F; Histone H2B type 3-B; histone H2B type F-M; Histone H2B type F-S; histone H2B type F-S-like; histone H2B type W-T; Histone H2B, testis; Histone H2B.1; histone H2B.1 A; Histone H2B.1 B; histone H2B.2; Histone H2B.a; histone H2B.b; Histone H2B.c; histone H2B.d; Histone H2B.e; histone H2B.f; Histone H2B.g; Histone H2B.h; Histone H2B.I; Histone H2B.j; histone H2B.k; Histone H2B.l; histone H2B.n; Histone H2B.q; histone H2B.r; Histone H2B.s; histone H2B-GL105; LOC102724334; MGC125414; MGC125415; MGC125416; MGC9388; R74621; RP1-193B12.10; STBP; T25626; testis-specific histone 2b; testis-specific histone H2B; Th2b; TSH2B; TSH2B.1
• Gene Symbols: H2B, H2bc1, H2BC10, H2BC11, H2BC12, H2BC13, H2BC14, H2BC15, H2BC17, H2bc18, H2BC21, H2BC3, H2BC4, H2BC5, H2BC8, H2BC9, H2BE1, H2BU1, H2BW1, H2BW2, LOC102724334
• Host Species: Rabbit
• Immunogen: Acetyl-peptide corresponding to Acetyl-Histone H2B (Lys20).
• Purification Method: Protein A
• Quantity: 100 μg
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 102724334, 114483833, 128312, 158983, 255626, 286436, 3017, 3018, 440689, 8339, 8340, 8341, 8342, 8345, 8346, 8347, 8348, 8349, 85236, 8970
• Target Species: Human, Monkey
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG