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Invitrogen™ ACK1 Polyclonal Antibody
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Catalog No. PIPA5111144
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100 μL
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PIPA5111144 100 μL
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Catalog No. PIPA5111144 Supplier Invitrogen™ Supplier No. PA5111144
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: FGVVRRGEWD APSGKTVSVA VKCLKPDVLS QPEAMDDFIR EVNAMHSLDH RNLIRLYGVV LTPPMKMVTE L Highest antigen sequence indentity to the following orthologs: Rat - 99%, Mouse - 97%.

TNK2 (ACK) (activated Cdc42-associated kinase) is a non-receptor tyrosine kinase that signals downstream of Cdc42. TNK2 is known to be involved in tumorigenesis and metastasis, particularly in prostate cancer. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ACK1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.6 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene TNK2
Gene Accession No. Q07912
Gene Alias ACK; ACK1; Ack-1; Activated CDC42 kinase 1; activated Cdc42-associated kinase 1; activated p21cdc42Hs kinase; Cdc42 GTPase-inhibiting protein; Cdgip; Non-receptor protein tyrosine kinase Ack; p21cdc42Hs; P21cdc42Hs kinase; Pyk1; Tnk2; tnk2 {ECO:0000250; tyrosine kinase non receptor 2; tyrosine kinase non-receptor protein 2; tyrosine kinase, non-receptor, 2; UniProtKB:Q07912}
Gene Symbols TNK2
Host Species Rabbit
Immunogen Recombinant Protein corresonding to Human ACK1. Recombinant protein control fragment (Product #RP-97242).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 10188
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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