ACL6B/BAF53b Rabbit anti-Human, Polyclonal, Bioss

Catalog No.	Quantity
50-198-1158	100 μL

Catalog No. 50-198-1158 Supplier Bioss Supplier No. BS11195R

Description

Rabbit Polyclonal Antibody

Belongs to the chromatin remodeling brain-specific BAF (bBAF) complex, as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex) and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth.

Specifications

• Antigen: ACL6B/BAF53b
• Applications: Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Gene: Actl6b
• Gene Accession No.: O94805
• Gene Alias: 53 kDa BRG1-associated factor B; actin like 6B; actin-like 6; actin-like 6B; Actin-like protein 6B; actin-like protein 6B {ECO:0000250; Actin-related protein Baf53b; Actl6; ACTL6B; actl6b {ECO:0000250; Arpna; ArpNalpha; ArpN-alpha; BAF53B; BRG1-associated factor 53B; hArpN alpha; UniProtKB:O94805}
• Gene Symbols: Actl6b
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from human ACL6B.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 51412
• Target Species: Human
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG