Invitrogen™ Aconitase 1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA577845

Catalog No. PIPA577845

Description

Positive Control: A431, HeLa, HepG2 Predicted Reactivity: Mouse (87%), Rat (86%), Rabbit (90%), Rhesus Monkey (99%), Bovine (89%) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Aconitase 1 (ACO1) also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). It plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.Aconitase 1, also known as iron regulatory element binding protein 1 (IREB1), is a cytosolic protein which binds to iron-responsive elements (IREs). IREs are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. The iron-induced binding to the IRE results in repression of translation of ferritin mRNA, and inhibition of degradation of the otherwise rapidly degrading transferrin receptor mRNA. Thus, IREB1 plays a central role in cellular iron homeostasis. It was also shown to have aconitase activity, and hence grouped with the aconitase family of enzymes.

Specifications

• Antigen: Aconitase 1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ACO1
• Gene Alias: ACO1; Aco-1; Acon1; Aconitase; aconitase 1; aconitase 1, soluble; aconitate hydratase, cytoplasmic; ACONS; AH; Citrate hydro-lyase; cytoplasmic aconitase; cytoplasmic aconitate hydratase; cytosplasmic aconitase; epididymis luminal protein 60; ferritin repressor protein; FRP; HEL60; Ireb1; Irebp; IRE-BP 1; IREBP1; iron regulatory protein 1; iron-responsive element binding protein 1; iron-responsive element-binding protein 1; IRP1; OTTHUMP00000021176; OTTHUMP00000021177; OTTHUMP00000045233; soluble aconitase
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 48
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: P21399
• Gene Symbols: ACO1
• Immunogen: Recombinant protein encompassing a sequence within the center region of human Aconitase 1. The exact sequence is proprietary.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG