Invitrogen™ ACOT2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5120270

Catalog No. PIPA5120270

Description

Positive test controls include: 293T, LO2, U-87MG, Mouse kidney. The target is usually found in the following locations: Mitochondrion. Immunogen sequence: IVDMFGTGGG LLEYRASLLA GKGFAVMALA YYNYEDLPKT METLHLEYFE EAMNYLLSHP EVKGPGVGLL GISKGGELCL SMASFLKGIT AAVVINGSVA NVGGTLHYKG ETLPPVGVNR NRIKVTKDGY ADIVDVLNSP LEGPDQKSFI PVERAESTFL FLVGQDDHNW KSEFYANEAC KRLQAHGRRK PQIICYPETG HYIEPPYFPL CRASLHALVG SPIIWGGEPR AHAMAQVDAW KQLQTFFHKH LGGHEGTIPS KV.

Acyl-CoA thioesterases (ACOTs) are a group of enzymes that catalyze the hydrolysis of acyl-CoA to form coenzyme A (CoA) and a free fatty acid. Through their catalytic activity, ACOTs are able to regulate the level of fatty acids and acyl-CoAs within the cell. ACOT1 (acyl-CoA thioesterase 1, also known as CTE1) and ACOT2 (acyl-CoA thioesterase 2, also known as PTE2) are members of the ACOT family and exhibit different cellular localization, with ACOT1 existing as a monomer in the cytoplasm and ACOT2 localized primarily to mitochondria. Characteristic of most ACOT proteins, ACOT1 and ACOT2 catalyze the conversion of Palmitoyl-CoA and water to free CoA and palmitate, a reaction that is important for the regulation of intercellular fatty acid levels. ACOT2 is expressed as multiple alternatively spliced isoforms and, like ACOT1, is encoded by a gene which maps to human chromosome 14.

Specifications

• Antigen: ACOT2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ACOT2
• Gene Alias: AA571646; Acot2; Acyl coenzyme A thioester hydrolase; acyl-CoA thioesterase 2; Acyl-coenzyme A thioester hydrolase 2a; acyl-coenzyme A thioesterase 2, mitochondrial; ARTISt/p43; CTE Ia; CTE1A; CTE-Ia; long-chain acyl-CoA thioesterase 2; mitochondrial acyl-CoA thioesterase 1; Mte1; MTE-I; peroxisomal long-chain acyl-coA thioesterase 2; PTE2; PTE2A; Very-long-chain acyl-CoA thioesterase; ZAP128
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10965, 171210, 192272
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Immunohistochemistry (Paraffin), Western Blot
• Concentration: 2.79 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: O55171, P49753, Q9QYR9
• Gene Symbols: ACOT2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 222-483 of human ACOT2 (NP_006812.3).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG