Invitrogen™ ACTR1A Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA593024

Catalog No. PIPA593024

Description

Immunogen sequence: GRDVSRFLRL YLRKEGYDFH SSSEFEIVKA IKERACYLSI NPQKDETLET EKAQYYLPDG STIEIGPSRF RAPELLFRPD LIGEESEGIH EVLVFAIQKS DMDLRRTLFS NIVLSGGSTL FKGFGDRLLS EVKKLAPKDV KIRISAPQER LYSTWIGGSI LASLDTFKKM WVSKKEYEED GARSIHRKTF; Positive Samples: MCF7, Mouse skeletal muscle, Mouse spleen, Mouse lung, Rat brain; Cellular Location: Cytoplasm, centrosome, cytoskeleton, microtubule organizing center.

This gene encodes a 42.6 kD subunit of dynactin, a macromolecular complex consisting of 10-11 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. It is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit is present in 8-13 copies per dynactin molecule, and is the most abundant molecule in the dynactin complex. It is an actin-related protein, and is approximately 60% identical at the amino acid level to conventional actin.

Specifications

• Antigen: ACTR1A
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ACTR1A
• Gene Alias: actin related protein 1A; actin-related protein 1 alpha; actin-related protein 1 homolog A; actin-RPV; ACTR1A; actr1a {ECO:0000250; alpha-Arp1; alpha-centractin; ARP1; ARP1 actin related protein 1 homolog A; ARP1 actin-related protein 1 homolog A, centractin alpha; ARP1 actin-related protein 1 homolog A, centractin alpha (yeast); ARP1 actin-related protein 1A, centractin alpha; Arp1 centractin alpha; Arp1 contractin alpha; Arp1A; centractin; Centrosome-associated actin homolog; CTRN1; FLJ52695; FLJ52800; FLJ55002; UniProtKB:P61163}; yeast homolog A
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 10121, 294010, 54130
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.44 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P61163, P61164, P85515
• Gene Symbols: ACTR1A
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 187-376 of human ACTR1A (NP_0057271).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG