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Invitrogen™ ACVR1B Polyclonal Antibody
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Catalog No. PIPA5101107
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100 μL
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PIPA5101107 100 μL
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Catalog No. PIPA5101107 Supplier Invitrogen™ Supplier No. PA5101107
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total ACV1B.

ACVR1B is a serine/threonine kinase involved in signal transduction and cellular communication. Several truncated ACVR1B isoforms have been reported to be exclusively expressed in human pituitary tumors. Mutations of ACVR1B have been observed in pancreatic adenocarcinomas. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1B encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ACVR1B
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene ACVR1B
Gene Accession No. P36896, P80202, Q61271
Gene Alias 6820432J04; activin A receptor type 1B; activin A receptor type IB; activin A receptor, type 1B; activin A receptor, type IB; activin A receptor, type II-like kinase 4; activin receptor type IB; Activin receptor type-1B; activin receptor-like kinase 4; ACTRI; ActRIB; ActR-IB; ACVR1A; Acvr1b; ACVRLK2; ACVRLK4; ALK2; Alk4; ALK-4; FOP; Serine/threonine-protein kinase receptor R2; SKR1; SKR2; TSRI
Gene Symbols ACVR1B
Host Species Rabbit
Immunogen A synthesized peptide derived from human ACVR1B(Accession P36896), corresponding to amino acid residues R91-I141.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11479, 29381, 91
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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