Invitrogen™ ACVR1B Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA520596

Catalog No. PIPA520596

Description

A suggested positive control is human kidney tissue lysate. PA5-20596 can be used with blocking peptide PEP-0716.

ACVR1B is a serine/threonine kinase involved in signal transduction and cellular communication. Several truncated ACVR1B isoforms have been reported to be exclusively expressed in human pituitary tumors. Mutations of ACVR1B have been observed in pancreatic adenocarcinomas. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. ACVR1B encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.

Specifications

• Antigen: ACVR1B
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ACVR1B
• Gene Alias: 6820432J04; activin A receptor type 1B; activin A receptor type IB; activin A receptor, type 1B; activin A receptor, type IB; activin A receptor, type II-like kinase 4; activin receptor type IB; Activin receptor type-1B; activin receptor-like kinase 4; ACTRI; ActRIB; ActR-IB; ACVR1A; Acvr1b; ACVRLK2; ACVRLK4; ALK2; Alk4; ALK-4; FOP; Serine/threonine-protein kinase receptor R2; SKR1; SKR2; TSRI
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11479, 91
• Content And Storage: Maintain refrigerated at 2°C to 8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P36896, Q61271
• Gene Symbols: ACVR1B
• Immunogen: A 14 amino acid peptide near the carboxy terminus of the human ACVR1B.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG