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ACVR1B Rabbit anti-Human, Polyclonal, Bioss
SDP

Catalog No. 501986978
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50-198-6978 100 μL
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Catalog No. 50-198-6978 Supplier Bioss Supplier No. BS6018R
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Description

Rabbit Polyclonal Antibody

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with a cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type IB receptor, composed of 11 exons. Alternative splicing and alternative polyadenylation result in 3 fully described transcript variants. The mRNA expression of variants 1, 2, and 3 is confirmed, and a potential fourth variant contains an alternative exon 8 and lacks exons 9 through 11, but its mRNA expression has not been confirmed.

Specifications

Antigen ACVR1B
Applications Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 μg/mL
Conjugate Unconjugated
Formulation PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
Gene ACVR1B
Gene Accession No. P36896
Gene Alias 6820432J04; activin A receptor type 1B; activin A receptor type IB; activin A receptor, type 1B; activin A receptor, type IB; activin A receptor, type II-like kinase 4; Activin receptor type IB; Activin receptor type-1B; Activin receptor-like kinase 4; ACTRI; ACTRIB; ACTR-IB; ACVR1A; Acvr1b; ACVRLK2; ACVRLK4; ALK2; ALK4; ALK-4; FOP; Serine/threonine-protein kinase receptor R2; SKR1; SKR2; TSRI
Gene Symbols ACVR1B
Host Species Rabbit
Immunogen KLH conjugated synthetic peptide derived from human ACVR1B.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 91
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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