Invitrogen™ ACVR1C Monoclonal Antibody (118311)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA523803

Catalog No. PIMA523803

Description

In Western blots, no cross-reactivity with recombinant human Activin R1B is observed. Reconstitute at 0.5 mg/mL in sterile PBS. Endoxin level is <0.10 EU per 1 μg of the antibody by the LAL method.

ACVR1C, a serine/threonine protein kinase, is a type I receptor for the TGFB family of signaling molecules. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors. ACVR1C is a receptor for activin AB, activin B and NODAL. This protein plays a role in cell differentiation, growth arrest and apoptosis.

Specifications

• Antigen: ACVR1C
• Classification: Monoclonal
• Concentration: 0.5 mg/mL
• Formulation: PBS with 5% trehalose and No Preservative
• Gene Accession No.: P70539
• Gene Symbols: ACVR1C
• Immunogen: Mouse myeloma cell line NS0-derived recombinant rat ALK-7 Leu26-Arg108.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Rat
• Product Type: Antibody
• Isotype: IgG2a

• Applications: Flow Cytometry, Western Blot
• Clone: 118311
• Conjugate: Unconjugated
• Gene: ACVR1C
• Gene Alias: activin A receptor type 1C; activin A receptor type IC; activin A receptor, type IC; activin receptor type IC; Activin receptor type-1C; activin receptor-like kinase 7; ACTRI; ACTR-IC; ACVR1A; acvr1c; acvr1c {ECO:0000312; ACVRLK2; ACVRLK7; ALK2; Alk7; ALK-7; C230097P10; EMBL:AAC52803.1}; FOP; habrec1; SKR1; TGF-beta type 1 receptor; TSRI
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 245921
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Lyophilized