ACVR2A Monoclonal Antibody (OTI1F2), TrueMAB™, OriGene

Mouse Monoclonal Antibody

Supplier:  OriGene TA807404

Catalog No. 50-168-1535

Description

This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I and two type II receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling, and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.

Specifications

• Antigen: ACVR2A
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene Accession No.: P27037
• Gene Symbols: ACVR2A
• Immunogen: Human recombit protein fragment corresponding to amino acids 214-513 of human ACVR2A produced in E.coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI1F2
• Conjugate: Unconjugated
• Gene: ACVR2A
• Gene Alias: ACTRII, ACVR2
• Host Species: Mouse
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 92
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Form: Liquid