Invitrogen™ ADAM15 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA596791

Catalog No. PIPA596791

Description

Positive Samples: Mouse heart, Mouse kidney, Mouse brain; Cellular Location: Cell junction, Cell projection, Cytoplasmic vesicle, Endomembrane system, Single-pass type I membrane protein, acrosome, adherens junction, cilium, flagellum, secretory vesicle Immunogen sequence: QPAAPLCLQT ANTRGNAFGS CGRNPSGSYV SCTPRDAICG QLQCQTGRTQ PLLGSIRDLL WETIDVNGTE LNCSWVHLDL GSDVAQPLLT LPGTACGPGL VCIDHRCQRV DLLGAQECRS KCHGHGVCDS NRHCYCEEGW APPDCTTQLK ATSSLTTGLL L.

The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.

Specifications

• Antigen: ADAM15
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Adam15
• Gene Alias: a disintegrin and metallopeptidase domain 15 (metargidin); a disintegrin and metalloprotease domain 15 (metargidin); a disintegrin and metalloproteinase; a disintegrin and metalloproteinase domain 15; a disintegrin and metalloproteinase domain 15 (metargidin); AD56; ADAM; ADAM 15; ADAM metallopeptidase domain 15; Adam15; ADAMs; CRII-7; disintegrin and metalloprotease 15; disintegrin and metalloproteinase domain-containing protein 15; Mdc15; MDC-15; metalloendopeptidases; Metalloprotease RGD disintegrin protein; metalloproteinase-like, disintegrin-like, and cysteine-rich protein 15; metargidin; tMDC VI; tMDCVI
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11490, 57025, 8751
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot, Immunocytochemistry
• Concentration: 1.34 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O88839, Q13444, Q9QYV0
• Gene Symbols: Adam15
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 540-700 of human ADAM15 (NP_0038063).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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