Invitrogen™ ADAM23 Polyclonal Antibody

Catalog No.	Quantity
PIPA575601	100 μL

Catalog No. PIPA575601 Supplier Invitrogen™ Supplier No. PA575601

Description

Rabbit Polyclonal Antibody

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).

ADAMs (a disintegrin and metalloproteinase domain), also known as MDCs (metalloproteinase, disintegrin, and cysteine-rich domain) or cellular disintegrins, are a family of proteins that are expressed in numerous different tissues. They catalyze proteolysis, adhesion, fusion and intracellular signaling. ADAMs are membrane-anchored proteins, and there are over 30 different members in the family with many diverse functions. ADAM 23 is exclusively expressed in fetal and adult brain and may function as an integrin ligand in cells of neural origin. Adhesion of neuroblastoma and astrocytoma cells is promoted by the disentegrin-like domain of ADAM23 and is mediated by an interaction of this protein with αvβ3. A short amino acid sequence in the disintegrin loop of ADAM23 interacts with αvβ3 to mediate cell interactions that take place during both normal and pathological processes. The three characteristic histidine residues and the glutamic acid residue typical of metalloproteinases are lacking in the metalloproteinase-like domain of ADAM23. This suggests that ADAM23 may not be involved in protease-mediated events, but could exclusively serve in cell adhesion processes. In addition, evidence suggests that ADAM23 may be a tumor suppressor gene.

Specifications

• Antigen: ADAM23
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene: ADAM23
• Gene Accession No.: O75077, Q9R1V7
• Gene Alias: a disintegrin and metallopeptidase domain 23; a disintegrin and metalloprotease domain 23; a disintegrin and metalloproteinase; ADAM; ADAM 23; ADAM metallopeptidase domain 23; ADAM23; ADAM-23; ADAMs; AW046396; disintegrin and metalloproteinase domain-containing protein 23; MDC3; MDC-3; metalloendopeptidases; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3
• Gene Symbols: ADAM23
• Host Species: Rabbit
• Immunogen: Synthetic peptide corresponding to residues in Human ADAM23.
• Purification Method: Antigen affinity chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 23792, 8745
• Target Species: Human, Mouse
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG