Invitrogen™ ADAMTS2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA587766

Catalog No. PIPA587766

Description

Positive Samples: A-375, U-87MG, THP-1, Rat thymus, ; Cellular Location: extracellular matrix, extracellular space Immunogen sequence: PRNISDPSKK SYVVQWLSRP DPDSPIRKIS SKGHCQGDKS IFCRMEVLSR YCSIPGYNKL CCKSCNLYNN LTNVEGRIEP PPGKHNDIDV FMPTLPVPTV AMEVRPSPST PLEVPLNASS TNATEDHPET NAVDEPYKIH GLEDEVQPPN LIPRRPSPYE KTRNQRIQEL IDEMRKKEML GKF.

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene excises the N-propeptide of type I, type II and type V procollagens. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in two transcript variants. The short transcript encodes a protein which has no significant procollagen N-peptidase activity.

Specifications

• Antigen: ADAMTS2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Adamts2
• Gene Alias: a disintegrin and metalloproteinase; A disintegrin and metalloproteinase with thrombospondin motifs 2; a disintegrin and metalloproteinase with thrombospondin repeats; a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 2; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 2; ADAM; ADAM metallopeptidase with thrombospondin type 1 motif 2; ADAM metallopeptidase with thrombospondin type 1 motif, 2; ADAMs; ADAM-TS 2; ADAMTS2; ADAM-TS2; ADAMTS-2; ADAMTS-3; hPCPNI; metalloendopeptidases; mKIAA4060; NPI; PC I-NP; PCINP; PCI-NP; PCPNI; PNPI; Procollagen I N-proteinase; procollagen I/II amino propeptide-processing enzyme; Procollagen N-endopeptidase; procollagen N-proteinase; RGD1565950
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 287899, 9509
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 2.88 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: O95450
• Gene Symbols: Adamts2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1029-1213 of human ADAMTS2 (O95450).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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