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ADAR1 Rabbit anti-Human, Polyclonal, Bethyl Laboratories
Rabbit Polyclonal Antibody
Supplier: Bethyl Laboratories, Inc A303883A

Description
The recommended shelf life for this product is 1 year from date of receipt. Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
ADAR catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2) and serotonin (HTR2C) and GABA receptor (GABRA3). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alters their functional activities.Specifications
ADAR1 | |
Polyclonal | |
Unconjugated | |
ADAR | |
136 kDa double-stranded RNA-binding protein, ADAR1, adenosine deaminase acting on RNA 1-A, adenosine deaminase, RNA-specific, AGS6, DRADA, DSH, DSRAD, dsRNA adenosine deaminase, dsRNA adeonosine deaminase, G1P1, IFI4, IFI-4, interferon-induced protein 4, interferon-inducible protein 4, K88DSRBP, P136 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
103 | |
4° C | |
Liquid |
Immunohistochemistry, Immunoprecipitation, Western Blot | |
1 mg/ml | |
phosphate, tris citrate with 0.09% sodium azide; pH 7-8 | |
P55265 | |
ADAR | |
Between 200 and 250 | |
100 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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