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Invitrogen™ ADC Polyclonal Antibody
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Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA531751

Catalog No. PIPA531751


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Description

Description

Recommended positive controls: SK-N-SH, human normal cerebellar. Predicted reactivity: Mouse (85%), Rat (86%), Dog (88%), Cat (88%), Pig (89%), Rabbit (90%), Sheep (86%), Rhesus Monkey (96%), Bovine (86%), Guinea pig (85%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Antizyme inhibitor 2 (AzI2), also known as arginine decarboxylase (ADC), is an enzyme that in humans is encoded by the AZIN2 gene. The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

ADC
Polyclonal
Unconjugated
AZIN2
4933429I20Rik; ADC; Antizyme inhibitor 2; ARGDC; arginine decarboxylase; Arginine decarboxylase-like protein; AZI2; AZIB1; AZIN2; B930082O19; KIAA1945; ODC antizyme inhibitor-2; ODC1L; ODC-like protein; Odcp; ODC-p; ODC-paralogue; ornithine decarboxylase like; ornithine decarboxylase paralog; Ornithine decarboxylase-like protein; ornithine decarboxylase-paralog; RGD1564776
Rabbit
Antigen affinity chromatography
RUO
113451
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Liquid
Western Blot
1.02 mg/mL
PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Q96A70
AZIN2
Recombinant protein encompassing a sequence within the center region of human ADC. The exact sequence is proprietary.
100 μL
Primary
Human
Antibody
IgG
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