Invitrogen™ ADC Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA590836

Catalog No. PIPA590836

Description

Immunogen sequence: MAGYLSESDF VMVEEGFSTR DLLKELTLGA SQATTDEVAA FFVADLGAIV RKHFCFLKCL PRVRPFYAVK CNSSPGVLKV LAQLGLGFSC ANKAEMELVQ HIGIPASKII CANPCKQIAQ IKYAAKHGIQ LLSFDNEMEL AKVVKSHPSA KMVLCIATDD SHSLSCLSLK FGVSLKSCRH LLENAKKHHV EVVGVSFHIG SGCPDPQAYA QSIADARLVF EMGTELGHKM HVLDLGGGFP GTEGAKVRFE EIASVINSAL DLYFPEGCGV DIFAELGRYY VTSAFTVAVS IIAKKEVLLD QPGREEENGS TSKTIVYHLD EGVYGIFNSV LFDNICPTPI LQKKPSTEQP LYSSSLWGPA; Positive Samples: U-87MG, Mouse pancreas, Mouse kidney; Cellular Location: Cell projection, Cytoplasm, Cytoplasmic granule, Cytoplasmic vesicle, Endoplasmic reticulum-Golgi intermediate compartment, Golgi apparatus, Membrane, Nucleus, Perikaryon, axon, cis-Golgi network, dendrite, perinuclear region, trans-Golgi network.

Antizyme inhibitor 2 (AzI2), also known as arginine decarboxylase (ADC), is an enzyme that in humans is encoded by the AZIN2 gene. The protein encoded by this gene belongs to the antizyme inhibitor family, which plays a role in cell growth and proliferation by maintaining polyamine homeostasis within the cell. Antizyme inhibitors are homologs of ornithine decarboxylase (ODC, the key enzyme in polyamine biosynthesis) that have lost the ability to decarboxylase ornithine; however, retain the ability to bind to antizymes. Antizymes negatively regulate intracellular polyamine levels by binding to ODC and targeting it for degradation, as well as by inhibiting polyamine uptake. Antizyme inhibitors function as positive regulators of polyamine levels by sequestering antizymes and neutralizing their effect. This gene encodes antizyme inhibitor 2, the second member of this gene family. Like antizyme inhibitor 1, antizyme inhibitor 2 interacts with all 3 antizymes and stimulates ODC activity and polyamine uptake. However, unlike antizyme inhibitor 1, which is ubiquitously expressed and localized in the nucleus and cytoplasm, antizyme inhibitor 2 is predominantly expressed in the brain and testis and localized in the endoplasmic reticulum-golgi intermediate compartment. Recent studies indicate that antizyme inhibitor 2 is also expressed in specific cell types in ovaries, adrenal glands and pancreas, and in mast cells. The exact function of this gene is not known, however, available data suggest its role in cell growth, spermiogenesis, vesicular trafficking and secretion.

Specifications

• Antigen: ADC
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: AZIN2
• Gene Alias: 4933429I20Rik; ADC; Antizyme inhibitor 2; ARGDC; arginine decarboxylase; Arginine decarboxylase-like protein; AZI2; AZIB1; AZIN2; B930082O19; KIAA1945; ODC antizyme inhibitor-2; ODC1L; ODC-like protein; Odcp; ODC-p; ODC-paralogue; ornithine decarboxylase like; ornithine decarboxylase paralog; Ornithine decarboxylase-like protein; ornithine decarboxylase-paralog; RGD1564776
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 113451, 242669
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 0.62 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q8BVM4, Q96A70
• Gene Symbols: AZIN2
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-360 of human AZIN2 (NP_4437241).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG