Adeno-Associated Virus Capsid Protein VP1 Rabbit anti-Virus, Polyclonal, Bioss

Catalog No.	Quantity
50-198-0738	100 μL

Catalog No. 50-198-0738 Supplier Bioss Supplier No. BS10180R

Description

Rabbit Polyclonal Antibody

Capsid protein self-assembles to form an icosahedral capsid with a T=1 symmetry, about 22 nm in diameter, and consisting of 60 copies of three size variants of the capsid protein VP1, VP2 and VP3 which differ in their N-terminus. The capsid encapsulates the genomic ssDNA. Binds to host cell heparan sulfate and uses host ITGA5-ITGB1 as coreceptor on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-dependent endocytosis. Binding to the host receptor also induces capsid rearrangements leading to surface exposure of VP1 N-terminus, specifically its phospholipase A2-like region and putative nuclear localization signal(s). VP1 N-terminus might serve as a lipolytic enzyme to breach the endosomal membrane during entry into host cell and might contribute to virus transport to the nucleus.

Specifications

• Antigen: Adeno-Associated Virus Capsid Protein VP1
• Applications: ELISA, Immunofluorescence, Immunohistochemistry (Paraffin), Western Blot
• Classification: Polyclonal
• Concentration: 1 μg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.09% sodium azide; pH
• Host Species: Rabbit
• Immunogen: KLH conjugated synthetic peptide derived from Adeno-Associated Virus 5 capsid protein VP1 .
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Virus
• Content And Storage: -20°C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG