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Tocris Bioscience™ Adenosine 5'-(a,b-methylene)diphosphate disodium salt
SDP

Catalog No. 817310 Shop All R&D Systems Products
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81-731-0 10 mg
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Catalog No. 81-731-0 Supplier Tocris Bioscience™ Supplier No. 8173/10
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Description

Ecto-5'-nucleotidase (CD73) inhibitor

Adenosine 5'-(α,β-methylene)diphosphate sodium salt is an ecto-5'-nucleotidase/CD73 inhibitor. Blocks ecto-5'-nucleotidase-mediated adenosine production by preventing the conversion of AMP to adenosine. Reverses doxorubicin -resistance in ecto-5'-nucleotidase-positive MDR cells (MCF7/A6 and L1210/A). Also increases rhodamine uptake and inhibits rhodamine efflux from ecto-5'-nucleotidase-positive MDR cells. Vasoconstrictor, induces inflammation in a rodent model of pleurisy, and reduces memory loss induced by Aβ1-42 in a mouse model of Alzheimer's disease.

Specifications

Chemical Name or Material α,β-Methyleneadenosine 5'-diphosphate disodium salt
CAS 104835-70-3
Quantity 10 mg
Target 5'-Nucleotidase/CD73
Molecular Formula C11H15N5Na2O9P2
Purity 0.98
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