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Invitrogen™ Adiponectin Receptor 2 Polyclonal Antibody
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Catalog No. PIPA5114166
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100 μL
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PIPA5114166 100 μL
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Catalog No. PIPA5114166 Supplier Invitrogen™ Supplier No. PA5114166
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: FPGKCDIWFH SHQLFHIFVV AGAFVHFHGV SNLQEFRFMI GGGCSEEDAL For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles. Predicted homology: Cow: 93%; Dog: 93%; Goat: 92%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 93%.

Adiponectin (also known as 30-kDa adipocyte complement-related protein; Acrp30) is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine. Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes. Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice. Conversely, adiponectin-deficient mice exhibit insulin resistance and diabetes. This insulin-sensitizing effect of adiponectin seems to be mediated by an increase in fatty-acid oxidation through activation of AMP kinase and PPAR. Here we report the cloning of complementary DNAs encoding adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) by expression cloning. AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver. These two adiponectin receptors are predicted to contain seven transmembrane domains, but are structurally and functionally distinct from G-protein-coupled receptors. Expression of AdipoR1/R2 or suppression of AdipoR1/R2 expression by small-interfering RNA supports our conclusion that they serve as receptors for globular and full-length adiponectin, and that they mediate increased AMP kinase and PPAR- ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectin.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Adiponectin Receptor 2
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.5 mg/mL
Conjugate Unconjugated
Formulation PBS with 2% sucrose and 0.09% sodium azide
Gene ADIPOR2
Gene Accession No. Q86V24
Gene Alias 1110001I14Rik; ACDCR2; ADCR2; adiponectin receptor 2; adiponectin receptor protein 2; Adipor2; AI115388; AW554121; D6Ucla1e; FLJ21432; MGC4640; Paqr2; Parq2; Progestin and adipoQ receptor family member 2; Progestin and adipoQ receptor family member II
Gene Symbols ADIPOR2
Host Species Rabbit
Immunogen Immunogen sequence: FPGKCDIWFH SHQLFHIFVV AGAFVHFHGV SNLQEFRFMI GGGCSEEDAL.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 79602
Target Species Human
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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