Invitrogen™ ADORA1 Recombinant Rabbit Monoclonal Antibody (10D12)

Catalog No.	Quantity
PIMA538319	100 μL

Catalog No. PIMA538319 Supplier Invitrogen™ Supplier No. MA538319

Description

Rabbit Recombinant Monoclonal Antibody

This antibody has been tested in direct-ELISA.

Adenosine receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily. Structural, biochemical and pharmacological analyses of the AR genes and protein has led to the discovery of four distinct AR subtypes (A1, A2a, A2b, A3). Activation of ARs mediates several receptor subtype-specific physiological processes that include cardiac rate, smooth muscle tone, platelet aggregation, inflammation, cell growth and death, and neurotransmission. The A1AR is a glycoprotein that can activate Gi and Go proteins in vitro. In intact cells, agonist occupation of the A1AR has been shown to cause pertussis toxin-sensitive inhibition of adenylyl cyclase activity and, in some systems, a stimulation of phospholipase C resulting in mobilization of intracellular calcium stores. Activation of potassium channels by A1AR has been intensively studied in relation to its dramatic effects on the cardiovascular system. A1AR protein is highly expressed in brain (especially cerebellum, hippocampus, thalamus, and cortex) and spinal cord and in part, modulates neurotransmitter release. In white adipocytes A1AR inhibits lipolysis and stimulates glucose uptake. Other tissues also express A1AR including kidney and testis.

Specifications

• Antigen: ADORA1
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Recombinant Monoclonal
• Clone: 10D12
• Concentration: 1.3 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 50% glycerol, 150mM NaCl and 0.02% sodium azide; pH 7.4
• Gene: ADORA1
• Gene Accession No.: P30542
• Gene Alias: A1AR; A1-AR; A1R; AA1R; adenosine A1 receptor; adenosine A1 receptor variant 1; adenosine A1 receptor variant 2; adenosine receptor A1; ADO-A1 receptor; ADORA1; AI848715; AR; BB176431; RDC7; Ri
• Gene Symbols: ADORA1
• Host Species: Rabbit
• Immunogen: A synthesized peptide derived from human ADORA1.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 134
• Target Species: Human
• Content And Storage: -20°C or -80°C if preferred
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG