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Invitrogen™ ADPGK Polyclonal Antibody
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Catalog No. PIPA599253
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100 μL
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PIPA599253 100 μL
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Catalog No. PIPA599253 Supplier Invitrogen™ Supplier No. PA599253
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total ADPGK.

The ADPGK gene encodes ADP-dependent glucokinase, an enzyme distinct from the ATP-dependent hexokinases as it employs adenosine diphosphate (ADP) rather than ATP to phosphorylate glucose to glucose-6-phosphate. This gene, initially identified in archaeal species, has been co-opted into mammalian systems where it plays roles primarily in glycolytic processes. Structurally, the mammalian ADPGK differs from its archaeal counterpart, exemplified by the rearrangement of its secondary structures, such as the alpha2 and alpha3 helices. These helices are replaced by an extended beta-strand region, indicating evolutionary adaptations for function in higher organisms like mice. Although its precise physiological role remains partially defined, ADPGK is notably expressed in both hematopoietic lineages and tumor tissues, suggesting potential significance in cancer biology and energy metabolism.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ADPGK
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene ADPGK
Gene Accession No. Q8VDL4, Q9BRR6
Gene Alias 2610017G09Rik; ADP dependent glucokinase; ADP-dependent glucokinase; ADPGK; Adp-gk; ATP-dependent glucokinase; C77577; EC 2.7.1.147; PSEC0260; RbBP-35; RGD1306103
Gene Symbols ADPGK
Host Species Rabbit
Immunogen A synthesized peptide derived from human ADPGK(Accession Q9BRR6), corresponding to amino acid residues V247-E297.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 315722, 72141, 83440
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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