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Invitrogen™ ADRA2B Polyclonal Antibody
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Catalog No. PIPA5109364
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100 μL
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PIPA5109364 100 μL
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Catalog No. PIPA5109364 Supplier Invitrogen™ Supplier No. PA5109364
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Description

Rabbit Polyclonal Antibody

ADRA2B Polyclonal Antibody for Western Blot, ELISA

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha 2B adrenergic receptor subtype was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. Alpha 2B adrenergic receptor gene contains no introns in either its coding or untranslated sequences.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ADRA2B
Applications ELISA, Western Blot
Classification Polyclonal
Concentration 1.08 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene ADRA2B
Gene Accession No. P18089, P19328, P30545
Gene Alias [a]2B; ADA2B; Adra2b; Adra-2b; ADRA2B adrenergic, alpha-2B-, receptor; ADRA2L1; ADRA2RL1; ADRARL1; Adrenergic alpha2B- receptor class III; adrenergic receptor, alpha 2b; adrenergic, alpha-2B-, receptor; Adrenergic, alpha2B-, receptor class III; adrenoceptor alpha 2B; alpha-2 adrenergic receptor subtype C2; alpha-2-adrenergic receptor-like 1; alpha2B; alpha-2B adrenergic receptor; Alpha-2B adrenoceptor; alpha-2B adrenoreceptor; ALPHA2BAR; alpha-2BAR; alpha2-C2; FAME2; G-protein coupled receptor; subtype alpha2-C2
Gene Symbols ADRA2B
Host Species Rabbit
Immunogen Synthetic peptide.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11552, 151, 24174
Target Species Human, Mouse, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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