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Invitrogen™ Adrenomedullin Monoclonal Antibody (1D2C2C10)
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Catalog No. ABS0270102
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400 μL
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Catalog No. Quantity
ABS0270102 400 μL
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Catalog No. ABS0270102 Supplier Invitrogen™ Supplier No. ABS0270102
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Description

Mouse Monoclonal Antibody

The epitope of this antibody has been mapped to a region within residues 22-52. This antibody shows no cross-reactivity to CGRP. In ELISA applications, the binding of this antibody is not inhibited by full-length adrenomedullin in solution up to a concentration of 1 μmol/L, but is inhibited by adrenomedullin (aa 22-52) in solution. NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL.

Adrenomedullin (ADM), a vasodilator produced by most contractile cells, is characterized by persistent hypotensive activity. ADM is involved in the regulation of fluid and electrolyte homeostasis and in the maintenance of cardiovascular functioning. In hypertensive patients, the level of ADM in plasma is upregulated. Natriuresis is a common systemic manifestation of aneurysmal subarachnoid hemorrhage. ADM has strong natriuretic actions. ADM-induced natriuresis is caused by an increase in glomerular filtration rate and a decrease in distal tubular sodium reabsorption. ADM is present both in the periphery and brain, and can exert central effects such as decreasing food ingestion.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Adrenomedullin
Applications ELISA, Western Blot
Classification Monoclonal
Clone 1D2C2C10
Concentration 1.01 mg/mL
Conjugate Unconjugated
Formulation PBS with 15mM sodium azide; pH 7.4
Gene ADM
Gene Accession No. P35318
Gene Alias ADM; Adrenomedullin; AM; AMpreproadrenomedullin; Ap; H39316; PAMP; preproadrenomedullin; proadrenomedullin N-20 terminal peptide; ProAM N-terminal 20 peptide; ProAM-N20; RATAP
Gene Symbols ADM
Host Species Mouse
Immunogen Synthetic peptide corresponding to residues 1-52 of human adrenomedullin.
Purification Method Protein A
Quantity 400 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 133
Target Species Human
Content And Storage 4°C, store in dark
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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