Invitrogen™ Adrenomedullin Monoclonal Antibody (1D2C2C10)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ ABS0270102

Catalog No. ABS0270102

Description

The epitope of this antibody has been mapped to a region within residues 22-52. This antibody shows no cross-reactivity to CGRP. In ELISA applications, the binding of this antibody is not inhibited by full-length adrenomedullin in solution up to a concentration of 1 μmol/L, but is inhibited by adrenomedullin (aa 22-52) in solution. NOTE: Concentration is lot-dependent and can vary from 0.85-1.15 mg/mL.

Adrenomedullin (ADM), a vasodilator produced by most contractile cells, is characterized by persistent hypotensive activity. ADM is involved in the regulation of fluid and electrolyte homeostasis and in the maintenance of cardiovascular functioning. In hypertensive patients, the level of ADM in plasma is upregulated. Natriuresis is a common systemic manifestation of aneurysmal subarachnoid hemorrhage. ADM has strong natriuretic actions. ADM-induced natriuresis is caused by an increase in glomerular filtration rate and a decrease in distal tubular sodium reabsorption. ADM is present both in the periphery and brain, and can exert central effects such as decreasing food ingestion.

Specifications

• Antigen: Adrenomedullin
• Classification: Monoclonal
• Concentration: 1.09 mg/mL
• Formulation: PBS with 15mM sodium azide; pH 7.4
• Gene Accession No.: P35318
• Gene Symbols: ADM
• Immunogen: Synthetic peptide corresponding to residues 1-52 of human adrenomedullin.
• Quantity: 400 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: ELISA, Western Blot
• Clone: 1D2C2C10
• Conjugate: Unconjugated
• Gene: ADM
• Gene Alias: ADM; Adrenomedullin; AM; AMpreproadrenomedullin; Ap; H39316; PAMP; preproadrenomedullin; proadrenomedullin N-20 terminal peptide; ProAM N-terminal 20 peptide; ProAM-N20; RATAP
• Host Species: Mouse
• Purification Method: Protein A/G
• Regulatory Status: RUO
• Gene ID (Entrez): 133
• Content And Storage: 4°C, store in dark
• Form: Liquid