Invitrogen™ Adrenomedullin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA5103107

Catalog No. PIPA5103107

Description

Antibody detects endogenous levels of total ADM.

Adrenomedullin (ADM), a vasodilator produced by most contractile cells, is characterized by persistent hypotensive activity. ADM is involved in the regulation of fluid and electrolyte homeostasis and in the maintenance of cardiovascular functioning. In hypertensive patients, the level of ADM in plasma is upregulated. Natriuresis is a common systemic manifestation of aneurysmal subarachnoid hemorrhage. ADM has strong natriuretic actions. ADM-induced natriuresis is caused by an increase in glomerular filtration rate and a decrease in distal tubular sodium reabsorption. ADM is present both in the periphery and brain, and can exert central effects such as decreasing food ingestion.

Specifications

• Antigen: Adrenomedullin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ADM
• Gene Alias: ADM; Adrenomedullin; AM; AMpreproadrenomedullin; Ap; H39316; PAMP; preproadrenomedullin; proadrenomedullin N-20 terminal peptide; ProAM N-terminal 20 peptide; ProAM-N20; RATAP
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11535, 133, 25026
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: P35318, P43145, P97297
• Gene Symbols: ADM
• Immunogen: A synthesized peptide derived from human ADM(Accession P35318), corresponding to amino acid residues G12-G62.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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