Invitrogen™ ADSL Monoclonal Antibody (OTI2D10)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA525263

Catalog No. PIMA525263

Description

ADSL Monoclonal Antibody for Western Blot, IHC (P), Flow

ADSL (adenylosuccinate lyase), also known as AMPS, ASL or ASASE, is a 484 amino acid protein that is involved in both purine biosynthesis and in the formation of adenosine monophosphate (AMP) from inosine monophosphate. Expressed ubiquitously, ADSL catalyzes two key reactions in AMP biosynthesis, namely the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and the subsequent removal of fumarate from adenylosuccinate to yield AMP. Defects in the gene encoding ADSL are the cause of adenylosuccinase deficiency (ADSL deficiency), an autosomal recessive disorder characterized by epilepsy, growth retardation and muscular wasting. Multiple isoforms of ADSL exist due to alternative splicing events.

Specifications

• Antigen: ADSL
• Classification: Monoclonal
• Concentration: 0.55 mg/mL
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide; pH 7.3
• Gene Accession No.: P30566, Q8HXY5
• Gene Symbols: Adsl
• Immunogen: Full length human recombinant protein of ADSL produced in HEK293T cell.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Rat, Canine, Cynomolgus Monkey
• Product Type: Antibody
• Isotype: IgG1

• Applications: Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
• Clone: OTI2D10
• Conjugate: Unconjugated
• Gene: Adsl
• Gene Alias: 2510006M18Rik; Adenylosuccinase; adenylosuccinate lyase; adenylosuccinate lyase 1; Adl; Adsl; AMPS; argininosuccinase; argininosuccinate lyase; Arginosuccinase; ASAL; ASase; ASL; null; test; unnamed protein product
• Host Species: Mouse
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 101864843, 158, 315150, 474499
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid