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Invitrogen™ ADSL Polyclonal Antibody
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Catalog No. PIPA5119795
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100 μL
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PIPA5119795 100 μL
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Catalog No. PIPA5119795 Supplier Invitrogen™ Supplier No. PA5119795
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Description

Rabbit Polyclonal Antibody

Positive Control: Jurkatcell lysate, NIH/3T3 cell lysate, mouse skeletal muscle tissue lysate, rat skeletal muscle tissue lysate, mouse brain tissue. Subcellular Location: Cytosol.

ADSL (adenylosuccinate lyase), also known as AMPS, ASL or ASASE, is a 484 amino acid protein that is involved in both purine biosynthesis and in the formation of adenosine monophosphate (AMP) from inosine monophosphate. Expressed ubiquitously, ADSL catalyzes two key reactions in AMP biosynthesis, namely the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and the subsequent removal of fumarate from adenylosuccinate to yield AMP. Defects in the gene encoding ADSL are the cause of adenylosuccinase deficiency (ADSL deficiency), an autosomal recessive disorder characterized by epilepsy, growth retardation and muscular wasting. Multiple isoforms of ADSL exist due to alternative splicing events.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ADSL
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
Gene Adsl
Gene Accession No. P30566, P54822
Gene Alias 2510006M18Rik; Adenylosuccinase; adenylosuccinate lyase; adenylosuccinate lyase 1; Adl; Adsl; AMPS; argininosuccinase; argininosuccinate lyase; Arginosuccinase; ASAL; ASase; ASL; null; test; unnamed protein product
Gene Symbols Adsl
Host Species Rabbit
Immunogen Synthetic peptide within N-terminal human AMPS.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 11564, 158, 315150
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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