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  5. Tocris Bioscience™ AEE 788

Tocris Bioscience™ AEE 788
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Catalog No. 531850
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Quantity:
10 mg
50 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Potent EGFR and VEGFR inhibitor

AEE 788 is a potent EGFR and VEGFR inhibitor (IC50 values are 2, 6, 59, 77, 160 and 330 nM for EGFR, ErbB2, VEGFR-1, VEGFR-2, ErbB4 and VEGFR-3 respectively). Also inhibits c-Abl, c-Fms and c-Src (IC50 values are 52, 60 and 61 nM respectively). Inhibits proliferation of EGFR and ErbB2 overexpressing cancer cell lines in vitro. Inhibits tumor xenograft growth and VEGF-induced angiogenesis in mice. Orally active.

Specifications

Quantity 50 mg
Product Type AEE 788
Purity >98%
Molecular Weight (g/mol) 440.58
Inhibitors AEE 788

For Research Use Only

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