AEG1 Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-156-4376	Bethyl Laboratories, Inc A303144AT	20 μL

Description

The recommended shelf life for this product is 1 year from date of receipt.

Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain; blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.

Specifications

• Antigen: AEG1
• Classification: Polyclonal
• Form: Liquid
• Regulatory Status: RUO
• Formulation: TBS with 0.1% BSA and 0.09% sodium azide
• Gene Alias: 3D3; AEG1; AEG-1; LYRIC; LYRIC/3D3; MTDH
• Immunogen: Between 300 and 350
• Primary or Secondary: Primary
• Content And Storage: 4° C
• Gene: MTDH

• Applications: Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Human, Mouse
• Gene Accession No.: Q80WJ7, Q86UE4
• Gene ID (Entrez): 67154, 92140
• Isotype: IgG
• Purification Method: Antigen affinity chromatography
• Product Type: Antibody