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AF9 Polyclonal Antibody, Bethyl Laboratories

Rabbit Polyclonal Antibody

$151.31 - $568.26

Specifications

Antigen AF9
Applications Immunohistochemistry
Classification Polyclonal
Conjugate Unconjugated
Form Liquid
View More Specs

Products 2
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
Catalog Number Mfr. No. Quantity Price Quantity & Availability  
50-157-1532
Encompass_Preferred
View Documents
Bethyl Laboratories, Inc
IHC00125T
10 μL
Each for $151.31
Only null left
Add to Cart
 
50-157-1531
Encompass_Preferred
View Documents
Bethyl Laboratories, Inc
IHC00125
100 μL
Each for $568.26
Only null left
Add to Cart
 
Description

Description

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Bovine, Dog, Horse, Rabbit, Pig, Orangutan, Monkey, Gorilla, Chimpanzee, Northern white-cheeked g

The human AF9 gene is one of the most common fusion partner genes with the ALL1 gene at 11q23 (also called MLL), resulting in the t(9;11)(p22;q23). The AF9 gene is more than 100 kb, and 2 patient breakpoint cluster regions (BCRs) have been identified; BCR1 is within intron 4, previously called site A, whereas BCR2 or site B spans introns 7 and 8. Several different structural elements have been identified in AF9, including a colocalizing in vivo DNA topo II cleavage site and an in vitro DNase I hypersensitive (DNase 1 HS) site in intron 7 in BCR2. Reversibility experiments demonstrated a religation of the topo II cleavage sites. In addition, 2 scaffold associated regions (SARs) are located centromeric to the topo II and DNase I HS cleavage sites and border breakpoint regions in 2 leukemic cells lines: SAR1 is located in intron 4, whereas SAR2 encompasses parts of exons 5-7. The patient breakpoint regions of AF9 share the same structural elements as the MLL BCR. A DNA breakage and repair model for nonhomologous recombination between MLL and its partner genes, particularly AF9, has been proposed.
Specifications

Specifications

AF9
Polyclonal
Liquid
RUO
TBS with 0.1% BSA and 0.09% sodium azide
AF-9 protein
MLLT3
IgG
Antigen affinity chromatography
Antibody
Immunohistochemistry
Unconjugated
Rabbit
Human
P42568
4300
Between 250 and 300
Primary
4° C
MLLT3
Videos
SDS
Documents

Documents

Product Certifications
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