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AF9 Polyclonal Antibody, Bethyl Laboratories
Rabbit Polyclonal Antibody
$151.31 - $568.26
Specifications
| Antigen | AF9 |
|---|---|
| Applications | Immunohistochemistry |
| Classification | Polyclonal |
| Conjugate | Unconjugated |
| Form | Liquid |
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
|---|---|---|---|---|---|---|---|---|---|
| Catalog Number | Mfr. No. | Quantity | Price | Quantity & Availability | |||||
50-157-1532
|
Bethyl Laboratories, Inc
IHC00125T |
10 μL |
Each for $151.31
|
|
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50-157-1531
|
Bethyl Laboratories, Inc
IHC00125 |
100 μL |
Each for $568.26
|
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Description
The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Bovine, Dog, Horse, Rabbit, Pig, Orangutan, Monkey, Gorilla, Chimpanzee, Northern white-cheeked g
The human AF9 gene is one of the most common fusion partner genes with the ALL1 gene at 11q23 (also called MLL), resulting in the t(9;11)(p22;q23). The AF9 gene is more than 100 kb, and 2 patient breakpoint cluster regions (BCRs) have been identified; BCR1 is within intron 4, previously called site A, whereas BCR2 or site B spans introns 7 and 8. Several different structural elements have been identified in AF9, including a colocalizing in vivo DNA topo II cleavage site and an in vitro DNase I hypersensitive (DNase 1 HS) site in intron 7 in BCR2. Reversibility experiments demonstrated a religation of the topo II cleavage sites. In addition, 2 scaffold associated regions (SARs) are located centromeric to the topo II and DNase I HS cleavage sites and border breakpoint regions in 2 leukemic cells lines: SAR1 is located in intron 4, whereas SAR2 encompasses parts of exons 5-7. The patient breakpoint regions of AF9 share the same structural elements as the MLL BCR. A DNA breakage and repair model for nonhomologous recombination between MLL and its partner genes, particularly AF9, has been proposed.Specifications
| AF9 | |
| Polyclonal | |
| Liquid | |
| RUO | |
| TBS with 0.1% BSA and 0.09% sodium azide | |
| AF-9 protein | |
| MLLT3 | |
| IgG | |
| Antigen affinity chromatography | |
| Antibody |
| Immunohistochemistry | |
| Unconjugated | |
| Rabbit | |
| Human | |
| P42568 | |
| 4300 | |
| Between 250 and 300 | |
| Primary | |
| 4° C | |
| MLLT3 |
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