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Invitrogen™ AFAP1L2 Monoclonal Antibody (2H6D1)
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Catalog No. PIMA531614
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100 μL
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Catalog No. Quantity
PIMA531614 100 μL
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Catalog No. PIMA531614 Supplier Invitrogen™ Supplier No. MA531614
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Description

Mouse Monoclonal Antibody

MA5-31614 has been tested in indirect ELISA.

AFAP1L2, also known as XB130, is structurally similar to actin-filament-associated protein (AFAP), containing several SH2- and SH3-binding motifs, two pleckstrin homology domains, a coiled-coil region, and many potential phosphorylation sites. It interacts with and is phosphorylated by c-Src tyrosine kinase. Suppression of AFAP1L2 via siRNA reduced Src activity, IL-8 production, EGF-induced phosphorylation of Akt and GSK3beta, and altered cell cycles in human lung epithelial cells suggesting that AFAP1L2 plays a role as an adaptor in the regulation of Src signal transduction and multiple cellular functions. Recent experiments have shown that AFAP1L2 is highly expressed in thyroid and is the substrate RET/PTC kinase, a thyroid-specific kinase that plays a pathogenic role in papillary thyroid cancer. Down-regulation of AFAP1L2 in these cancer cells reduced Akt activity, inhibiting cell-cycle progression and cancer cell survival in suspension, indicating that AFAP1L2 may be a valuable target in thyroid cancer therapy. At least four isoforms of AFAP1L2 are known to exist.
TRUSTED_SUSTAINABILITY

Specifications

Antigen AFAP1L2
Applications ELISA, Flow Cytometry, Western Blot
Classification Monoclonal
Clone 2H6D1
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.05% sodium azide
Gene AFAP1L2
Gene Accession No. Q8N4X5
Gene Alias actin filament associated protein 1 like 2; actin filament associated protein 1-like 2; actin filament-associated protein 1-like 2; Afap1l2; AFAP1-like protein 2; AU041783; C86904; CTB-1144G6.4; CTB-1144G6.6; KIAA1914; mKIAA1914; phosphatidylinositol 3-kinase-associated protein; RGD1310668; XB130
Gene Symbols AFAP1L2
Host Species Mouse
Immunogen Purified recombinant fragment of human AFAP1L2 (AA: 674-818) expressed in E. coli.
Purification Method Protein G
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 84632
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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