Invitrogen™ AFAP1L2 Monoclonal Antibody (2H6D1)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA531614

Catalog No. PIMA531614

Description

MA5-31614 has been tested in indirect ELISA.

AFAP1L2, also known as XB130, is structurally similar to actin-filament-associated protein (AFAP), containing several SH2- and SH3-binding motifs, two pleckstrin homology domains, a coiled-coil region, and many potential phosphorylation sites. It interacts with and is phosphorylated by c-Src tyrosine kinase. Suppression of AFAP1L2 via siRNA reduced Src activity, IL-8 production, EGF-induced phosphorylation of Akt and GSK3beta, and altered cell cycles in human lung epithelial cells suggesting that AFAP1L2 plays a role as an adaptor in the regulation of Src signal transduction and multiple cellular functions. Recent experiments have shown that AFAP1L2 is highly expressed in thyroid and is the substrate RET/PTC kinase, a thyroid-specific kinase that plays a pathogenic role in papillary thyroid cancer. Down-regulation of AFAP1L2 in these cancer cells reduced Akt activity, inhibiting cell-cycle progression and cancer cell survival in suspension, indicating that AFAP1L2 may be a valuable target in thyroid cancer therapy. At least four isoforms of AFAP1L2 are known to exist.

Specifications

• Antigen: AFAP1L2
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with 0.05% sodium azide
• Gene Accession No.: Q8N4X5
• Gene Symbols: AFAP1L2
• Immunogen: Purified recombinant fragment of human AFAP1L2 (AA: 674-818) expressed in E. coli.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Flow Cytometry, Western Blot
• Clone: 2H6D1
• Conjugate: Unconjugated
• Gene: AFAP1L2
• Gene Alias: actin filament associated protein 1 like 2; actin filament associated protein 1-like 2; actin filament-associated protein 1-like 2; Afap1l2; AFAP1-like protein 2; AU041783; C86904; CTB-1144G6.4; CTB-1144G6.6; KIAA1914; mKIAA1914; phosphatidylinositol 3-kinase-associated protein; RGD1310668; XB130
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 84632
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid