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Invitrogen™ AFF1 Polyclonal Antibody
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Catalog No. PIPA567082
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100 μL
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PIPA567082 100 μL
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Catalog No. PIPA567082 Supplier Invitrogen™ Supplier No. PA567082
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: VDLIKFIMSLK SFSDATAPTQ EKIFAVLCMR CQSILNMAMF RCKKDIAIKY SRTLNKHFES SSK Highest antigen sequence identity to the following orthologs - mouse 73%, rat 80%.

Proto-oncogene AF-4 (or FEL) is a product of a chromosomal aberration of the human gene AFF1, which is associated with acute leukemias. The fusion of AF-4 on chromosome band 4q21 with the mixed lineage leukemia (MLL or HRX) gene on 11q23 results in a MLL-AF-4 chimeric transcription factor in which AF-4 contributes transcriptional effector properties and requires cell-specific accessory factors. MLL is involved in several chromosomal translocations associated with acute myeloid and lymphoid leukemia. The MLL-AF-4 fusion protein is expressed in all normal hematopoietic cells.
TRUSTED_SUSTAINABILITY

Specifications

Antigen AFF1
Applications Immunocytochemistry
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene AFF1
Gene Accession No. P51825
Gene Alias 9630032B01Rik; AF4; AF4/FMR2 family member 1; AF4/FMR2 family, member 1; AFF1; ALL1-fused gene from chromosome 4 protein; AW319193; FEL; homolog of human MLLT2 unidentified; MLLT2; Mllt2h; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2; myeloid/lymphoid or mixed-lineage leukemia translocated to 2 homolog; PBM1; pre-B-cell monocytic leukemia partner 1; protein AF-4; Protein FEL; Proto-oncogene AF4; Rob; robotic; translocated to, 2
Gene Symbols AFF1
Host Species Rabbit
Immunogen Recombinant Human AFF1. Recombinant protein control fragment (Product #RP-107722).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 4299
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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