Invitrogen™ AFF1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA567082

Catalog No. PIPA567082

Description

Immunogen sequence: VDLIKFIMSLK SFSDATAPTQ EKIFAVLCMR CQSILNMAMF RCKKDIAIKY SRTLNKHFES SSK Highest antigen sequence identity to the following orthologs - mouse 73%, rat 80%.

Proto-oncogene AF-4 (or FEL) is a product of a chromosomal aberration of the human gene AFF1, which is associated with acute leukemias. The fusion of AF-4 on chromosome band 4q21 with the mixed lineage leukemia (MLL or HRX) gene on 11q23 results in a MLL-AF-4 chimeric transcription factor in which AF-4 contributes transcriptional effector properties and requires cell-specific accessory factors. MLL is involved in several chromosomal translocations associated with acute myeloid and lymphoid leukemia. The MLL-AF-4 fusion protein is expressed in all normal hematopoietic cells.

Specifications

• Antigen: AFF1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: AFF1
• Gene Alias: 9630032B01Rik; AF4; AF4/FMR2 family member 1; AF4/FMR2 family, member 1; AFF1; ALL1-fused gene from chromosome 4 protein; AW319193; FEL; homolog of human MLLT2 unidentified; MLLT2; Mllt2h; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 2; myeloid/lymphoid or mixed-lineage leukemia translocated to 2 homolog; PBM1; pre-B-cell monocytic leukemia partner 1; protein AF-4; Protein FEL; Proto-oncogene AF4; Rob; robotic; translocated to, 2
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 4299
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunocytochemistry
• Concentration: 0.25 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P51825
• Gene Symbols: AFF1
• Immunogen: Recombinant Human AFF1. Recombinant protein control fragment (Product #RP-107722).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG